. Author manuscript; available in PMC: 2006 Aug 1.

Published in final edited form as: Epilepsy Behav. 2005 Aug;7(1):57–67. doi: 10.1016/j.yebeh.2005.04.008

Table 3.

Criteria for corticosteroid-induced genomic and nongenomic effects [54]

Criterion	Genomic effects	Nongenomic effects
1. Temporal (time lag to effects)	More than 15 min	Considerably earlier than 15 min^a
2. MR/GR dependence/independence	Blockade of MR/GR abolishes the effects (receptor dimers only)	Blockade of MR/GR has no effects
3. Genome dependence/independence	Blockade of protein synthesis prevents the effects^b	Blockade of protein synthesis has no effects

Corticosteroid effects occurring between 10 and 20 min can be attributed to a nongenomic mechanism only if another argument supports this assumption.

However, genomic corticosteroid effects mediated by inhibition of gene expression are not affected.