Table 4.
GR homodimers | MR homodimers | GR/MR heterodimers | GR monomers | |
---|---|---|---|---|
Transcriptional activity | Via DNA GR-responsive element | Weak agonists at DNA GR-responsive element | DNA binding distinct from GR or MR homodimers | Via transcription factors without DNA binding |
Co-regulator | Required | Required | N/Ab | Not required |
Anxiety effects | No | N/A | N/A | Yes |
Ref. | [63,66,68] | [68,120] | [121,122] | [63,66,68] |
See also [11].
N/A, information not available.