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. 1984 Mar;25(3):228–231. doi: 10.1136/gut.25.3.228

Survival of patients with colorectal cancer complicating ulcerative colitis.

S N Gyde, P Prior, H Thompson, J A Waterhouse, R N Allan
PMCID: PMC1432285  PMID: 6698437

Abstract

The crude five year survival of patients with colorectal cancer complicating ulcerative colitis in a large series of patients under long term review has, for the first time, been compared with the survival of patients with colorectal cancer in the general population (West Midlands region) from which the colitic patients were drawn. Thirty five cases of colorectal cancer were diagnosed in 676 patients with ulcerative colitis between 1944 and 1976. An actuarial five year survival curve was computed for the colitic and non-colitic patients with colorectal cancer. In ulcerative colitis patients with cancer the five year survival was 33.5% (range 16.9-50.1%) compared with 32.6% (28.2-37.0%) in the non-colitic cancer patients drawn from the relevant general population. Overall the prognosis is much better than earlier reports suggest. It is perhaps disappointing that in a closely monitored group the outcome is only as good as that in the general population. Surveillance programmes should improve the outcome in those patients with ulcerative colitis who accept the need for regular review.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blackstone M. O., Riddell R. H., Rogers B. H., Levin B. Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Gastroenterology. 1981 Feb;80(2):366–374. [PubMed] [Google Scholar]
  2. Bülow S. Colorectal cancer in patients less than 40 years of age in Denmark, 1943-1967. Dis Colon Rectum. 1980 Jul-Aug;23(5):327–336. doi: 10.1007/BF02586840. [DOI] [PubMed] [Google Scholar]
  3. De Dombal F. T., Watts J. M., Watkinson G., Goligher J. C. Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum. Br Med J. 1966 Jun 11;1(5501):1442–1447. doi: 10.1136/bmj.1.5501.1442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Devroede G. J., Taylor W. F., Sauer W. G., Jackman R. J., Stickler G. B. Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med. 1971 Jul 1;285(1):17–21. doi: 10.1056/NEJM197107012850103. [DOI] [PubMed] [Google Scholar]
  5. Hughes R. G., Hall T. J., Block G. E., Levin B., Moossa A. R. The prognosis of carcinoma of the colon and rectum complicating ulcerative colitis. Surg Gynecol Obstet. 1978 Jan;146(1):46–48. [PubMed] [Google Scholar]
  6. Hultén L., Kewenter J., Ahrén C., Ojerskog B. Clinical and morphological characteristics of colitis carcinoma and colorectal carcinoma in young people. Scand J Gastroenterol. 1979;14(6):673–678. doi: 10.3109/00365527909181936. [DOI] [PubMed] [Google Scholar]
  7. Kewenter J., Ahlman H., Hultén L. Cancer risk in extensive ulcerative colitis. Ann Surg. 1978 Dec;188(6):824–828. doi: 10.1097/00000658-197812000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lavery I. C., Chiulli R. A., Jagelman D. G., Fazio V. W., Weakley F. L. Survival with carcinoma arising in mucosal ulcerative colitis. Ann Surg. 1982 Apr;195(4):508–512. doi: 10.1097/00000658-198204000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lennard-Jones J. E., Morson B. C., Ritchie J. K., Shove D. C., Williams C. B. Cancer in colitis: assessment of the individual risk by clinical and histological criteria. Gastroenterology. 1977 Dec;73(6):1280–1289. [PubMed] [Google Scholar]
  10. Lennard-Jones J. E., Morson B. C., Ritchie J. K., Shove D. C., Williams C. B. Cancer in colitis: assessment of the individual risk by clinical and histological criteria. Gastroenterology. 1977 Dec;73(6):1280–1289. [PubMed] [Google Scholar]
  11. Prior P., Gyde S. N., Macartney J. C., Thompson H., Waterhouse J. A., Allan R. N. Cancer morbidity in ulcerative colitis. Gut. 1982 Jun;23(6):490–497. doi: 10.1136/gut.23.6.490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ritchie J. K., Hawley P. R., Lennard-Jones J. E. Prognosis of carcinoma in ulcerative colitis. Gut. 1981 Sep;22(9):752–755. doi: 10.1136/gut.22.9.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SHANDS W. C., DOCKERTY M. B., BARGEN J. A. Adenocarcinoma of the large intestine associated with chronic ulcerative colitis; clinical and pathologic features of 73 cases. Surg Gynecol Obstet. 1952 Mar;94(3):302–310. [PubMed] [Google Scholar]
  14. SLANEY G., BROOKE B. N. Cancer in ulcerative colitis. Lancet. 1959 Oct 31;2(7105):694–698. doi: 10.1016/s0140-6736(59)92130-0. [DOI] [PubMed] [Google Scholar]
  15. SLOAN W. P., Jr, BARGEN J. A., GAGE R. P. Life histories of patients with chronic ulcerative colitis: a review of 2,000 cases. Gastroenterology. 1950 Sep;16(1):25–38. [PubMed] [Google Scholar]
  16. van Heerden J. A., Beart R. W., Jr Carcinoma of the colon and rectum complicating chronic ulcerative colitis. Dis Colon Rectum. 1980 Apr;23(3):155–159. doi: 10.1007/BF02587618. [DOI] [PubMed] [Google Scholar]

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