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. 2003 Jan;71(1):309–316. doi: 10.1128/IAI.71.1.309-316.2003

FIG. 4.

FIG. 4.

Vaccination with pVR1020-GRA1 induced CD8+ T cells with specific GRA1 cytolytic activity. (A) Cytotoxic activities of effectors from pVR1020-vaccinated (▪), pVR1020-GRA1-vaccinated (▾), and pVR1020-GRA1-vaccinated CD8+ T-cell-depleted (•) C3H mice against BW-Sp3(GRA1) targets. Effector cells were stimulated for 6 days with irradiated BW-Sp3(GRA1) cells. The data are the means from three independent experiments. (B) Cytotoxic activities of effectors from pVR1020-vaccinated (▪), pVR1020-GRA1-vaccinated (▾), and pVR1020-GRA1-vaccinated CD8+ T-cell-depleted (•) C3H mice against T. gondii-infected syngeneic bone marrow macrophages. Effector cells were stimulated for 6 days with tachyzoites from the T. gondii IPB-M strain. The data are the means from three independent experiments. E, effector cells; T, target cells.