TABLE 1.

Maximum tolerated dose of MSO in guinea pigs

MSO concn (mg kg−1 day−1)	Ascorbate (3 mmol kg−1 day−1)a	No. of animals tested	% of animals dying	Median days to death
100	−	3	100	1
50	−	3	100	2
25	−	5	100	2.5
12.5	−	2	100	4
6.25	−	3	33	5
3.13	−	3	0
1.56	−	3	0
25	+	3	100	6
12.5	+	3	0
6.25	+	3	0
3.13	+	3	0
1.56	+	3	0

^a−, absent; +, present.