TABLE 2.
Course of P. marneffei infection in wild-type and GKO BALB/c micea
| Days postinfection | Mean CFU (103)/g ± SD in the following organs in the indicated mice:
|
|||
|---|---|---|---|---|
| Spleens
|
Livers
|
|||
| Wild type | GKOb | Wild type | GKO | |
| 7 | 30.2 ± 7.9 | 66.9 ± 8 | 59.8 ± 6 | 73.1 ± 4 |
| 14 | 34.5 ± 10 | 1,392 ± 57 | 41.1 ± 9 | 292 ± 47 |
a
Mice were injected i.v. with 4 × 105 conidia. At the indicated time postinfection, the organs were excised and processed. Fungus growth was evaluated by counting CFU on YMA in triplicate after 72 h. There were three mice per group. Statistical analyses were performed by analysis of variance by comparing each experimental group from GKO mice to the corresponding wild-type control group at different times postinfection. P values for spleens at days 7 and 14 were <0.05 and <0.0001, respectively. P values for livers at days 7 and 14 were <0.04 and <0.002, respectively.
b
All GKO mice died of generalized mycosis on day 18 postinfection.