FIG. 4.

Effect of LOS on PGE₂ production in cocultures. The cocultures were treated with LOS (10 μg/ml) with or without polymyxin B (Poly) (50 μg/ml) for 24 h. The PGE₂ concentration was determined by using a PGE₂ enzyme immunoassay kit. The data are the means ± standard errors for three cultures. One asterisk indicates that the P value is <0.05 for a comparison with the results for the nontreated cultures. Two asterisks indicate that the P value is <0.05 for a comparison with the results for the LOS-treated cultures.