Abstract
The lack of information on survival in young adults with cirrhosis and the increasing use of liver transplantation in this age group have led us to carry out a retrospective analysis of the clinical course and survival in 83 young adults aged between 15 and 30 years presenting to the Liver Unit between 1970 and 1983. Fifty four (65%) patients had cirrhosis at initial presentation and in the remaining 29 (35%) this developed within the study period. The overall five year survival of the group, excluding 14 cases treated by transplantation, was 70%. When considered according to aetiological groups this was 83% in those with chronic active hepatitis, 60% in those with cryptogenic cirrhosis and 37% in Wilson's disease. When considered in relation to Child's grading, only three deaths occurred in the 45 patients with well-compensated liver disease (Child's grade A and B). Of the 38 patients with Child's grade C, 20 (83%) of the 24 patients not undergoing transplantation have died, whereas eight (57%) of the 14 receiving liver grafts are alive and well.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Czaja A. J., Davis G. L., Ludwig J., Taswell H. F. Complete resolution of inflammatory activity following corticosteroid treatment of HBsAg-negative chronic active hepatitis. Hepatology. 1984 Jul-Aug;4(4):622–627. doi: 10.1002/hep.1840040409. [DOI] [PubMed] [Google Scholar]
- Kirk A. P., Jain S., Pocock S., Thomas H. C., Sherlock S. Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis. Gut. 1980 Jan;21(1):78–83. doi: 10.1136/gut.21.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pugh R. N., Murray-Lyon I. M., Dawson J. L., Pietroni M. C., Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973 Aug;60(8):646–649. doi: 10.1002/bjs.1800600817. [DOI] [PubMed] [Google Scholar]
- Saunders J. B., Walters J. R., Davies A. P., Paton A. A 20-year prospective study of cirrhosis. Br Med J (Clin Res Ed) 1981 Jan 24;282(6260):263–266. doi: 10.1136/bmj.282.6260.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scott J., Gollan J. L., Samourian S., Sherlock S. Wilson's disease, presenting as chronic active hepatitis. Gastroenterology. 1978 Apr;74(4):645–651. [PubMed] [Google Scholar]
- Sternlieb I. Wilson's disease: indications for liver transplants. Hepatology. 1984 Jan-Feb;4(1 Suppl):15S–17S. doi: 10.1002/hep.1840040706. [DOI] [PubMed] [Google Scholar]
- Stone W. D., Islam N. R., Paton A. The natural history of cirrhosis. Experience with an unselected group of patients. Q J Med. 1968 Jan;37(145):119–132. [PubMed] [Google Scholar]
- Williams R., Calne R. Y., Rolles K., Polson R. J. Current results with orthotopic liver grafting in Cambridge/King's College Hospital series. Br Med J (Clin Res Ed) 1985 Jan 5;290(6461):49–52. doi: 10.1136/bmj.290.6461.49. [DOI] [PMC free article] [PubMed] [Google Scholar]