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. 2003 Jan;71(1):575–579. doi: 10.1128/IAI.71.1.575-579.2003

FIG. 2.

FIG. 2.

When mice were challenged with M. tuberculosis 4 weeks after vaccination with optimal doses of either the plasmid DNA replicon pSINCP-85A or the conventional plasmid pcDNA3-85A, a similar degree of protection was observed. Mice were vaccinated subcutaneously with various doses of plasmid DNA, twice, 2 weeks apart; 4 weeks after the second DNA immunization, mice were infected by aerosol with M. tuberculosis. Four weeks after infection, five mice from each group were sacrificed, and lungs were removed for viable bacterial counts. Data points represent the geometric mean number of CFU per lung from three to five mice plus or minus standard error. *, P < 0.05 compared with naïve mice.

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