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. 2003 Jan;71(1):196–204. doi: 10.1128/IAI.71.1.196-204.2003

FIG. 2.

FIG. 2.

Anti-4-1BB MAb inhibits the primary anti-PspA response and the generation of PspA-specific memory independent of CD8+ T cells. Mice (five per group) were immunized with R36A in combination with anti-CD8 and/or anti-4-1BB MAb and/or control rat IgG. Mice were boosted with R36A alone 6 weeks after primary immunization and then boosted again 2 weeks later. Sera were obtained on days 7 (anti-PC) and 14 (primary anti-PspA) and at 8 weeks (secondary anti-PspA) and 10 weeks (tertiary anti-PspA) for the determination of titers of anti-PC and/or anti-PspA Ig isotypes by ELISA. Data are representative of two similar experiments. ∗, P ≤ 0.05 relative to that for rat Ig.