Table 2.
Effects of drugs on fundic distension rate (dl/dt)
| IGP (mmH2O) | ||||
|---|---|---|---|---|
| 10 | 20 | 30 | 40 | |
| control | 12.4±4.9 (9) | 11.6±3.9 (9) | 26.8±8.9 (9) | 37.5±10.5 (9) |
| Sumatriptan (0.1 mg/kg, iv) | 7.1±1.2 (9) | 24.6±5.8 (9)** | 49.3±12.8 (9)* | 59.2±12.9 (9)** |
| control | 9.9±5.9 (4) | 15.8±7.6 (4) | 21.3±9.1 (4) | 34.2±13.7 (4) |
| Buspirone | 12.6±8.0 (4) | 24.1±20 (4) | 30.8±21.8 (4) | 41.1±17.3 (4) |
| (0.1 mg/kg, iv) | ||||
| control | 5.3±4.4 (4) | 13.0±11.4 (4) | 21.1±15.7 (4) | 29.8±19.1 (4) |
| Atropine | 4.9±1.3 (4) | 11.5±0.7 (4) | 16.7±7.7 (4) | 30.8±18.2 (4) |
| (0.4 mg/kg, im) | ||||
| control | 8.4±3.0 (3) | 13.2±2.6 (3) | 16.2±1.0 (3) | 16.1±1.8 (3) |
| Bethanechol | −21.6±17.8 (3) | 0.7±1.5 (3)* | 3.0±0.6 (3)* | 7.2±1.8 (3)** |
| (0.15 mg/kg, iv) | ||||
| control | 15.5±3.1 (5) | 24.5±3.4 (5) | 38.1±4.8 (5) | 43.8±5.1 (5) |
| L-NNA | −2.4±1.4 (3)* | −1.2±1.5 (3)* | 10.1±2.3 (3)* | 7.4±3.5 (3)** |
| 1.5 mg/kg, iv) | ||||
Intragastric pressure (IGP) is the pressure above baseline (60mmH2O)
Values shown as μm/min. Numbers in parenthesis indicate the number of animals
*
=P<0.05
**
=P<0.001