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. Author manuscript; available in PMC: 2006 Sep 13.
Published in final edited form as: Oncogene. 2006 Mar 13;25(11):1649–1658. doi: 10.1038/sj.onc.1209374

Figure 3.

Figure 3

Each bar represents Mean ± SD for the isoniazid elimination rate constant (top) or the area under the concentration-time curve (bottom) following a single oral dose of 5 or 10 mg/kg isoniazid in individuals with homozygous rapid acetylator genotype (black), heterozygous acetylator genotype (gray) or homozygous slow acetylator genotype (white). NAT2 genotypes and phenotypes were 100% concordant and differences among the genotypes were highly significant (p<0.0001) following one way analysis of variance. Adapted from Parkin et al., 1997.