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In vivo efficacy of vancomycin 1200 mg/kg/day (red squares) compared with sterile saline (black squares) against S. aureus GRP-0057 in the neutropenic mouse thigh infection model. Immunosupression achieved with a low-dose (250 mg/kg) cyclophosphamide regimen; treatment administrated every 3 hours by subcutaneous injections. Each data-point represents the mean ± standard deviation from both thighs of 2–4 mice (unseen error bars are contained within symbols).
