Table 1.
Leukocytes counts of female Udea:ICR(CD-1) mice at baseline and after treatment with a low-dose cyclophosphamide regimen. Total number of leukocytes (cells/mm3) and differential count in peripheral blood of 10 mice at baseline in day 1 (8 hours prior to first dose), at day 4 (8 hours prior to second dose), during immunosupression (days 5–7), and at recovery (day 11), compared with reference values for 6 week-old mice.
| White blood-cell Population | Cells/mm3 (± SEM) | Normal Range | |||||
| Day 1 | Day 4 | Day 5 | Day 6 | Day 7 | Day 11 | ||
| Total Leukocytes | 5155 (405) | 845 (104) | 370 (84) | 610 (94) | 620 (179) | 5863 (1103) | 1000–5000 |
| Neutrophils | 528 (50) | 0 (0) | 10 (10) | 0 (0) | 36 (31) | 1700 (321) | 110–2150 |
| Lymphocytes | 4256 (395) | 831 (100) | 337 (72) | 517 (95) | 419 (124) | 2905 (415) | 500–4300 |
| Monocytes | 371 (74) | 14 (7) | 14 (9) | 93 (29) | 166 (76) | 1248 (604) | 10–300 |