Table 1.

Clinical Characteristics of enrolled subjects by genotype (N = 266).

Clinical characteristics	HbSS N = 148	HbSC N = 85	HbSβ0 N = 6	HbSβ+ N = 22	Sickle variants* N = 5
Age yr	26.4 ± 2.6	27 ± 2.3	25.9 ± 2.3	26.5 ± 2.5	25.1 ± 2.5
†Gender (M:F)	71:77	38:47	2:4	13:9	4:1
#Creatinine μmol/L	45.7 ± 9.4a	63.3 ± 11.7b	70.7 ± 23.1b	61.9 ± 12.4b	62 ± 20.4a
#Uric Acid mmol/L	0.3 ± 0.1a	0.3 ± 0.1a	0.4 ± 0.1a	0.4 ± 0.3b	0.3 ± 0.1a
#Haemoglobin g/L	80.2 ± 9.9a	108.2 ± 8b	91.6 ± 11.8b	109.9 ± 12.4b	124 ± 22.1b
#Nucleated Blood cells × 109/Lc	15.9 ± 3.2a	10.2 ± 2.9b	13.3 ± 2.2b	9.2 ± 2.7b	9.9 ± 2.5b
†Proteinuria ≥ trace : No proteinuria (n = 182)	17	7	0	1	0
†Positive History of gram negative sepsis	2	2	0	0	0
†Positive recorded history of ever having UTI	50	25	2	1	1

Values are means ± sd ; † values are counts. Abbreviations – HbSS = Homozygous sickle cell disease, HbSC= Sickle cell-haemoglobin C, HbSβ⁰ = Sickle cell-β⁰ thalassemia, HbSβ⁺ = Sickle cell-β⁺ thalassemia; UTI= Urinary Tract Infections.

* Sickle variants include sickle cell-hereditary persistence of foetal haemoglobin, sickle cell -haemoglobin O Arab, sickle cell -haemoglobin Lepore-Boston.

# Significant difference in mean values by genotype. Dissimilar superscript to HbSS values are significantly different (p < 0.03)