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. 1984 May;45(5):873–880. doi: 10.1016/S0006-3495(84)84233-2

Photoalteration of calcium channel blockade in the cardiac Purkinje fiber.

M C Sanguinetti, R S Kass
PMCID: PMC1434971  PMID: 6329345

Abstract

Organic compounds that block calcium channel current (calcium antagonists) are important tools for the characterization of this channel. However, the practically irreversible nature of this block restricts the usefulness of this group of drugs. In this paper, we investigate the influence of light on calcium channel blockade by several organic compounds. Our results show that inhibition of calcium channel current by two dihydropyridine derivatives that contain an o-nitro moiety (nisoldipine and nifedipine) can be rapidly reversed by illumination. The energy range important to this reaction is for light wavelengths between 320 and 450 nm. Calcium channel inhibition by two other dihydropyridine derivatives (nicardipine and nitrendipine) as well as by D600, is not modulated by illumination. These results indicate that the photosensitivity of certain dihydropyridine calcium channel blockers make these compounds useful as reversible blockers of this channel.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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