Table 3.

Configural frequency analysis of differences between early users vs. other users in the sequence of onset of abuse and dependence diagnoses

Substance	Abuse onset			Total N	Omnibus row χ2	χ2 Difference in sequences
	Before dependence	Same year as dependence	After dependence
Onset differences
Alcohol
Early a	191(43),76%b	44,18%	15(1),6%c	250	213.70d	6.37d
Othersa	405(201),75%b	73,14%c	59(16),11%c	537	428.56d
Cannabis
Earlya	123(62),55%	57,26%	43(13),19%	223	49.11d	9.66d
Othersa	164(112),65%b	36,14%	51(29),20%	251	83.67d
Cocaine
Earlya	27(9),11%	193,80%b	21(8),9%c	241	237.24d	38.61d
Others a	101(31),27%	209,56%b	65(17),17%	375	89.86d
Opiates
Earlya	21(9),38%	24,43%	11(5),20%	56	4.96d	0.65
Others	47(23),32%	70,47%	32(9),21%	149	14.75d

Notes: Separate configural frequency analyses were conducted for each substance among persons with either or both abuse and dependence. Percentiles indicate the proportion of the total number of participants that experienced a disorder associated with the row substance in the column sequence. Some row percentiles may not sum to 100% because of rounding error. Parenthetical values indicate the ‘n’ experiencing either abuse only (in the “before dependence” column) or dependence only (in the “after dependence” column). “Total N” is slightly lower than number of persons meeting lifetime criteria for both abuse and dependence in Table 1 because of missing age of onset data.

^aFrequencies of the sequences differed significantly from random order.

^bSequence was common, compared to chance (Type).

^cSequence was rare, compared to chance (Antitype).

^dDifference in sequences of onset of disorders was significant (p< .025).