Patient surgically treated for a left-sided floor of the mouth cancer, abutting the mandible; rim resection of the mandible was included, and the patient received postoperative irradiation. Baseline CT study, 6 months after completion of therapy, shows expected post-therapeutic changes, but also a more or less nodular area in front of the hyoid bone, without clear enhancement (A, arrowheads); based on these findings, a follow-up CT study was recommended. Three months later, a larger and enhancing nodular lesion is seen in the same region: suspect for recurrent tumour (B, arrowheads). Clinically no evidence of recurrent tumour was present. Based on the radiological findings, resection was performed about a month later and confirmed tumour recurrence.