Table 2.
Durie–Salmon staging system [8]
| Stage | Criteria | Cell mass |
|---|---|---|
| I | All of the following: | Low |
| Haemoglobin > 10 g / 100 ml | <0.6×1012 cells / mm 2 | |
| Normal serum calcium < 12 mg / 100 ml | ||
| Normal bone structure or solitary bone lesion only on radiography | ||
| Low M component production rates | ||
| IgG < 5 g / 100 ml | ||
| IgA < 3 g / 100 ml | ||
| Urine light chain M component on electrophoresis < 4 g / 24 h | ||
| II | Fitting neither stage I nor stage III | Intermediate |
| III | One or more of the following: | High |
| Haemoglobin < 8.5 g / 100 ml | >1.2×1012 cells / mm 2 | |
| Serum calcium > 12 mg / 100 ml | ||
| Advanced lytic bone lesion | ||
| High M component production rates | ||
| IgG > 7 g / 100 ml | ||
| IgA > 5 g / 100 ml | ||
| Urine light chain M component on electrophoresis > 12 g / 24 h | ||
Subclassifications: A = relatively normal renal function (serum creatinine value < 20 mg/100 ml [175 mmol/l]); B = abnormal renal function (serum creatinine value > 20 mg/100 ml [175 mmol/l]).