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. 2006 Apr 13;116(5):1391–1399. doi: 10.1172/JCI27540

Figure 2. Suppressive effects of IP deletion on vascular reactivity, platelet aggregation, and thrombogenesis are gene/dose dependent.

Figure 2

(A) The maximum decline (P < 0.0001) and duration (P < 0.005) of hypotension evoked in mean arterial pressure (MAP) by 1 μg/kg of IP agonist, cicaprost (Cica), was greater in WT than in IP+/– or IP–/– mice on a C57BL/6 background. (B) Platelet aggregation was initiated with 2 μg/ml collagen with (+) or without (–) pretreatment with 10 nM Cica. Inhibition of aggregation was not evident in IP–/– mice and averaged 86% of WT in IP+/– mice (P < 0.0001). (C) Carotid artery blood flow after photochemical injury. The time to complete occlusion after rose bengal dye injection fell from 66.3 ± 5.1 minutes in WT to 44.4 ± 7 minutes in IP+/– and to 29.7 ± 7.6 minutes in IP–/– mice (P < 0.006). The mean impact of the COX-2 inhibitor, DFU (10 mg/kg for 3 days), on time to occlusion (56.2% of WT value) was intermediate between that of IP+/– (68.1%) and IP–/– (45.5%) mice.