Table 3.
Top scoring SMID-BLAST ligand hits for TrpRS and TyrRS across a wide range of organisms. 82 TrpRS sequences and 83 TyrRS sequences were employed. The expected best ligand is shown in bold.
| Ligand to TrpRS | Hits | Ligand to TyrRS | Hits | |
| Top scoring ligand, ignoring ATP and Mg++ | Tryptophanyl Adenylate | 80 | Tyrosinal Adenylate | 37 |
| Tyrosinal | 2 | SB-239629 | 18 | |
| Tryptophanyl Adenylate | 13 | |||
| SB-243545 | 9 | |||
| SB-284485 | 5 | |||
| D-tyrosine | 1 | |||
| Top scoring ligand, ignoring ATP, Mg++ and binding site occupancy | Tryptophanyl Adenylate | 36 | SB-239629 | 50 |
| L-tryptophan | 22 | D-tyrosine | 31 | |
| D-tyrosine | 10 | Tyrosinal Adenylate | 1 | |
| SB-239629 | 7 | Tyrosinal | 1 | |
| Tyrosinal | 6 | |||
| L-tryptophanamide | 1 |