Figure 3.

Manually curated IL-1 pathway. Nodes and links in common with the automatically built IL-1 regulome pathway shown on Figure 4 are highlighted in blue. Graph legend: IL-1 is shown as red rhombus, Kinases – red sickle shapes, Proteases – brown sickle shapes, receptors – red stick shapes, Transcription factors – red O-shapes, Other proteins – red ovals; Binding – violet links, ProtModification – brown links, DirectRegulation – gray links with green rectangles, PromoterBinding – green links, Expression – blue link.