Figure 4.

Automatically built pathway. Nodes and links in common with manually curated IL-1 pathway shown on Figure 3 are highlighted in blue. Note that the set of proteins unique to automatically built pathway represents a classical MAP kinase cascade. It has been suggested only recently that the IL-1 receptor appears to activate a MAP kinase cascade by interaction with other members of the Toll-like receptor superfamily [17]. Obviously, older review articles used for construction of the manually curated IL-1 pathway did not mention this information. For graph legend see figure 3.