TABLE 2.

Degrees of centrilobular hepatic necrosis in mice treated with saline or APAP. The livers were examined histologically and classed according to the degree of centrilobular hepatocyte necrosis, marked as none, mild, moderate, or severe. Mice found dead 24 h after the APAP treatment were also noted. The numbers indicate how many mice were classed with which degree of hepatocyte necrosis per total number of mice examined in each group (total numbers of mice in each group, n = 5–10)

Genotype	Saline	APAP (200 mg/kg)	APAP (400 mg/kg)
Wild-type	None 5/5	None 3/5	Moderate 5/7
		Mild 1/5	Found dead 2/7
		Moderate 1/5
Cyp2e1-null	None 5/5	None 6/6	None 5/5
CYP2E1-humanized	None 8/8	None 9/9	Mild 3/10
			Moderate 2/10
			Severe 4/10
			Found dead 1/10