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. 2006 Apr 4;3(5):e141. doi: 10.1371/journal.pmed.0030141

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Concentration of drug in the bloodstream declines over time and falls below threshold levels permissive for growth of parasites with varying degrees of resistance. Dashed lines represent permissive thresholds for RS, R1, and R2 parasites. Adapted from Hastings et al. [ 11]. RS, drug-sensitive parasites; R1, partially resistant parasites; R2, fully resistant parasites.