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. 2006 Apr;80(7):3310–3321. doi: 10.1128/JVI.80.7.3310-3321.2006

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Copyright © 2006, American Society for Microbiology

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FIG. 5. — Role of CBV3 2A^pro in modulation of IRES-dependent translation. (A) Genetic structure of wt PV1 (top) and a chimeric PV1/CBV3 2A virus (bottom) encoding CBV3 2A^pro in a PV1(M) background. The autoproteolytic cleavage site for CBV3 2A^pro (P1-P2) is indicated (arrow). The amino acid sequence of the P1-P2 junction of PV1(M), CBV3, and the chimera are shown. (B) One-step growth kinetics of parental PV1(M), CBV3, and the PV1/CBV3 2A chimera. (C) Effect of infection with specified viruses on rLuc expression levels. (D) Comparison of eIF4GI degradation rates in HeLa cells infected at an MOI of 10 with PV1(M), CBV3, or the PV1/CBV3 2A chimera.