FIG. 2.

Dose-dependent effects of ribavirin, MPA, viramidine, l-FMAU, alpha interferon, and pegylated alpha interferon on the accumulation of processed HDV RNA transcripts. The data shown in panel A represent quantitation of the results from Fig. 1. Panels B to F represent quantitations of similar studies using not ribavirin but MPA, viramidine, l-FMAU, alpha interferon, and pegylated alpha interferon, respectively. In all panels, the columns of dark, medium, and light blue refer to accumulation of transcripts by Pol I (18S rRNA), Pol III (tRNA), and Pol II (DNA-directed mRNA for δAg), respectively. Similarly, the red-shaded columns refer to HDV unit-length genomic RNA, unit-length antigenomic RNA, and RNA-directed HDV mRNA (from darkest to lightest red, respectively). For data obtained using ³²P-labeled probes, we subtracted the signal detected prior to the drug treatment. In all cases, the data were normalized relative to the accumulations detected in the absence of drug treatment.