FIG. 2.

Kinetics of IFN-α and IFN-β after FV infection. Mice were infected with FV, and blood was collected at the indicated time points postinfection. IFN-α and IFN-β levels were determined in the plasma by ELISA. (A) Kinetics of IFN-α production was determined for two mouse strains susceptible to FV-induced leukemia and two resistant mouse strains. (B) Kinetics of IFN-α production was compared with that of IFN-β production in susceptible (B10.A × A.BY)F₁ mice. Four animals per group were analyzed. Standard deviations are indicated by a bar. was documented by spleen weights (A), and viral loads were measured in the spleen (B) and in the blood (C). The mean value for each group is indicated by a bar. Differences between the control group and the two groups of IFN-α-treated mice were analyzed by using Dunnett's multiple-comparison correction test. Statistically significant differences between the groups are indicated.