FIG. 4.

Productive replication of RRV is independent of that of rhEBV. RRV-infected B-cell lines and corresponding parental cell lines were fixed and hybridized in situ simultaneously with a SpectrumRed-labeled RRV probe and a SpectrumGreen-labeled rhEBV probe. Cell nuclei were counterstained with DAPI (blue). Results are shown for the RRV-infected 211-98 cell line. Panels: A, latent coinfection of RRV and rhEBV; B, productive replication of RRV in the presence of latent rhEBV; C, productive replication of rhEBV in the presence of latent RRV infection. Note that in panel B, three rhEBV-positive cells are present that are apparently not infected by RRV.