FIG. 8.

Replication of wt and φ mutant virus in MDBK cells. Cells were infected with VSV or the φ mutant recombinant virus at an MOI of 10 or 0.1. At 24 h p.i., the cells were analyzed as follows. (A) Virus titers were determined from cells infected at high or low MOI. Wild-type control (▪); hydrophobic mutant (□). The titers shown are the means (plus standard deviations) of the results from three separate experiments using media from cells at 24 h p.i. (B) Phase-contrast imaging showing rwt-infected cells in the top images and cells infected by mutant virus in the bottom images.