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Inhibition of gp120JRFL binding to sCD4 by BMS-488043 and BMS-378806. Inhibitor activity was measured with the gp120-sCD4 binding ELISA. (A) Effect of sCD4 concentration on the inhibitory activity of AI against gp120-sCD4 binding (IC50, concentration needed to inhibit gp120-sCD4 binding by 50%). (B) Effect of AI concentration on the apparent affinity (KD) of sCD4 for gp120. BMAX, maximal sCD4 bound to gp120. OD450nm, optical density at 450 nm.
