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Effect of BMS-488043 on gp120-MAb binding. Binding of a conformation-sensitive MAb to gp120JRFL was measured with a gp120-MAb binding ELISA with various concentrations of BMS-488043 added. (A) Binding of CD4BS to gp120. (B) Antibody binding to CD4-induced epitopes in the absence of sCD4. (C) Binding of V3 loop MAb to gp120. compd, compound.
