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The presence of tetrapeptide E66QIV69 and hexapeptide G82QVLAL87 from CCP1 of bovine CD46 leads to gain of receptor function of porcine CD46. SK6T cell lines were constructed that express the tetrapeptide and the hexapeptide in a chimeric CD46 molecule containing various parts of porcine CD46. The susceptibility to BVDV was assayed in the absence and presence of Dox. The columns represent mean values of duplicate experiments; error bars indicate maximum and minimum values.
