FIG. 3.

Inflammatory effects of RAdhsFlt3L delivered into the brain of Lewis rats. (A) ED1 quantification. (B) MHCI quantification. (C) MHCII quantification. (D) CD8 quantification. Quantification of the area occupied by ED1, MHCI, MHCII, and CD8 immunoreactivity, 48 h, 7 days, and 14 days post-intrastriatal injection was performed using a semiautomatic Quantimet imaging system. Serial sections were studied and infiltration was determined using the sections displaying the largest amounts of infiltration per brain, per treatment. Error bars show the SEM value from four animals in each experimental group. ED1, MHCI, MHCII, and CD8 immunoreactivities observed in each experimental group were compared to one another at each time point using an unpaired Student t test; the results are presented in the tables next to each bar graph (ns, not significant).