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. 2006 Apr 20;116(5):1337–1345. doi: 10.1172/JCI27400

Figure 1. CD2AP haploinsufficiency enhances proteinuria in Fyn-deficient mice.

Figure 1

(A) Mice were tested monthly for proteinuria. The incidence of proteinuria is depicted as both percentages and absolute numbers for the indicated mouse genotypes followed to up to 12 months of age. The onset of proteinuria is shown below for each genotype in months ± SEM. *Statistical significance. (B) Sections of formalin-fixed kidney cortex from 5- to 8-month-old mice were stained with H&E and with PAS. In Fyn–/– mice, most glomeruli were normal (top right). Representative glomeruli from Fyn+/–Cd2ap+/– mice (middle row) or Fyn–/–Cd2ap+/– mice (bottom row) taken 2 months after the onset of proteinuria reveal mesangial hypercellularity and segmental sclerosis or global sclerosis in some glomeruli. Magnification, ×400.