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. 2006 Apr 20;116(5):1337–1345. doi: 10.1172/JCI27400

Figure 3. Bigenic Cd2ap and Synpo heterozygosity lead to proteinuria and FSGS.

Figure 3

(A) Mice were screened monthly for proteinuria. The incidence of proteinuria is depicted as both percentages and absolute numbers for the indicated mouse genotypes followed for up to 12 months. The onset of proteinuria is shown below for each proteinuric genotype in months ± SEM and did not differ among genotypes. *Statistical significance. (B) Sections of formalin-fixed kidney cortex from 6- to 9-month-old mice were stained with H&E and with PAS. In wild-type, Synpo–/–, and CD2AP+/– mice, nearly all glomeruli were normal (top panel). Representative glomeruli from Synpo+/–Cd2ap+/– mice (middle row) or Synpo–/–Cd2ap+/– mice (bottom row) 2 months after the onset of proteinuria showed mesangial hypercellularity and segmental or global sclerosis in some but not all glomeruli. Magnification, ×400.