FIGURE 2.

The various antiparallel and parallel arrangements of β-strands in the β-sheet oligomer which are simulated in this work. The oligomers shown are snapshots from the simulation of Aβ24–26. All models consist of two sheets, each with four strands. In some sheets (anti2, anti3, para3), the strands are shifted with respect to each other within the sheet. In some models (e.g., para2 and para4), the sheets are shifted with respect to each other. The sequence given is for Aβ25–35. Hyrdrophobic regions are in red. (A–C) Antiparallel oligomers. (D) Two parallel oligomers (para1 and para2). (E–F) Two parallel ologimers.