Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Apr 21;2(4):e57. doi: 10.1371/journal.pgen.0020057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2006 Fitzgerald et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Alignment of a region of EGL-30 containing the M244I amino acid substitution with other G-proteins. The conserved methionine residue that is mutated to isoleucine in the egl-30(ep271) allele is indicated in bold text and underlined.

(B) Diagram showing the domain structure of the EAT-16 protein with relative locations of the E158K substitution found in the eat-16(ep273) allele, and the splice site mutation found in eat16(ad702) strains.

(C) Genetic interactions between mutations in G-αq and RGS. The G-αq/egl-30(ep271) and RGS/eat-16(ad702) mutations confer resistance to BMS-192364. The sensitivity of a G-αq/egl-30(pk931) strain to BMS-192364 is abrogated in the presence of the eat-16(ad702) mutation.