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. Author manuscript; available in PMC: 2006 May 1.
Published in final edited form as: Arch Oral Biol. 2005 Nov 14;51(5):433–438. doi: 10.1016/j.archoralbio.2005.09.010

Figure 2.

Figure 2

Twsg1−/− embryos display widely variable craniofacial phenotypes at E13.5. Normal craniofacial phenotypes are seen in Twsg1+/− (A). Twsg1−/− embryo display craniofacial phenotypes that range from normal mandibular arch development (with or without associated defects such as microphthalmia (B) to simple agnathia with a hypoplastic mandibular arch (arrow), low set ears and microstomia (C) to severe holoprosencephaly/agnathia with no mandibular arch (arrowhead) or grossly evident stomodeum (D). e—eye. Bar, 200 mm.