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. 2006 Apr 25;4(5):e142. doi: 10.1371/journal.pbio.0040142

Figure 7. Mechanisms for Selective Assembly of a Diverse Group of Receptors with their Signaling Modules.

Figure 7

The Fcγ and DAP12 signaling modules are expressed by a variety of different cell types of hematopoietic origin and serve as signaling subunits for many different receptors. Fcγ and DAP12 exhibit a preference for a particular basic side chain, Fcγ for arginine (R) and DAP12 for lysine (K). The location of the ionizable TM residues also contributes to specificity of assembly, an aspect that is important because Fcγ and DAP12 are co-expressed by a number of different cell types. The DAP10 signaling dimer assembles only with NKG2D and initiates signaling through interaction with the p85 subunit of PI-3 kinase, while the other two adaptors signal through ZAP-70 or Syk tyrosine kinases.