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. 1977 May;32(5):803–810.

Susceptibility of human lymphocyte populations to infection by herpes simplex virus.

B K Pelton, R C Imrie, A M Denman
PMCID: PMC1445301  PMID: 301117

Abstract

The antibody response to diphtheria toxoid by cultured tonsil cells was suppressed by herpes simplex virus during its inductive stage. Since only T lymphocytes readily supported virus replication, this immunosuppression may be attributed to a selective effect of the virus on this population of cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bentwich Z., Douglas S. D., Skutelsky E., Kunkel H. G. Sheep red cell binding to human lymphocytes treated with neuraminidase; enhancement of T cell binding and identification of a subpopulation of B cells. J Exp Med. 1973 Jun 1;137(6):1532–1537. doi: 10.1084/jem.137.6.1532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown G., Greaves M. F. Cell surface markers for human T and B lymphocytes. Eur J Immunol. 1974 Apr;4(4):302–310. doi: 10.1002/eji.1830040414. [DOI] [PubMed] [Google Scholar]
  3. Cerny J., McAlack R. F., Geglowski W. S., Friedman H. Divergence between immunosuppression and immunocompetence during virus-induced leukemogenesis. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1862–1865. doi: 10.1073/pnas.68.8.1862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dahl H., Degre M. Separation of antiviral activity of human interferon from cell growth inhibitory effect. Nature. 1975 Oct 30;257(5529):799–800. doi: 10.1038/257799a0. [DOI] [PubMed] [Google Scholar]
  5. Datta S. K., Schwartz R. S. Autoimmunization and graft versus host reactions. Transplant Rev. 1976;31:44–78. doi: 10.1111/j.1600-065x.1976.tb01452.x. [DOI] [PubMed] [Google Scholar]
  6. Dracott B. N., Wedderburn N., Salaman M. H. In vitro immune responses of spleen cells from Friend virus infected mice. J Gen Virol. 1972 Jan;14(1):77–86. doi: 10.1099/0022-1317-14-1-77. [DOI] [PubMed] [Google Scholar]
  7. Geha R. S., Schneeberger E., Rosen F. S., Merler E. Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes. J Exp Med. 1973 Nov 1;138(5):1230–1247. doi: 10.1084/jem.138.5.1230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Greaves M. F., Brown G. Epstein-Barr virus binding sites on lymphocyte subpopulations and the origin of lymphoblasts in cultured lymphoic cell lines and in the blood of patients with infectious mononucleosis. Clin Immunol Immunopathol. 1975 Mar;3(4):514–524. doi: 10.1016/0090-1229(75)90076-8. [DOI] [PubMed] [Google Scholar]
  9. Hersey P., Edwards A., Edwards J. Characterization of mononuclear effector cells in human blood. Clin Exp Immunol. 1976 Jan;23(1):104–113. [PMC free article] [PubMed] [Google Scholar]
  10. Hotchin J. Transient virus infection: spontaneous recovery mechanism of lymphocytic choriomeningitis virrus-infected cells. Nat New Biol. 1973 Feb 28;241(113):270–272. doi: 10.1038/newbio241270a0. [DOI] [PubMed] [Google Scholar]
  11. Johnson H. M., Smith B. G., Baron S. Inhibition of the primary in vitro antibody response by interferon preparations. J Immunol. 1975 Jan;114(1 Pt 2):403–409. [PubMed] [Google Scholar]
  12. Klinman N. R., Taylor R. B. General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. Clin Exp Immunol. 1969 Apr;4(4):473–487. [PMC free article] [PubMed] [Google Scholar]
  13. Marbrook J. Primary immune response in cultures of spleen cells. Lancet. 1967 Dec 16;2(7529):1279–1281. doi: 10.1016/s0140-6736(67)90393-5. [DOI] [PubMed] [Google Scholar]
  14. McFarland H. F. The effect of measles virus infection on T and B lymphocytes in the mouse. I. Suppression of helper cell activity. J Immunol. 1974 Dec;113(6):1978–1983. [PubMed] [Google Scholar]
  15. Miller R. G., Phillips R. A. Separation of cells by velocity sedimentation. J Cell Physiol. 1969 Jun;73(3):191–201. doi: 10.1002/jcp.1040730305. [DOI] [PubMed] [Google Scholar]
  16. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  17. Platts-Mills T. A., Ishizaka K. IgA and IgA diphtheria antitoxin responses from human tonsil lymphocytes. J Immunol. 1975 Mar;114(3):1058–1064. [PubMed] [Google Scholar]
  18. Rager-Zisman B., Merigan T. C. A useful quantitative semimicromethod for viral plaque assay. Proc Soc Exp Biol Med. 1973 Apr;142(4):1174–1179. doi: 10.3181/00379727-142-37202. [DOI] [PubMed] [Google Scholar]
  19. Rasmussen L., Farley L. B. Inhibition of Herpesvirus hominis replication by human interferon. Infect Immun. 1975 Jul;12(1):104–108. doi: 10.1128/iai.12.1.104-108.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Scheinberg M., Blacklow N. R., Goldstein A. L., Parrino T. A., Rose F. B., Cathcart E. S. Influenza: response of T-cell lymphopenia to thymosin. N Engl J Med. 1976 May 27;294(22):1208–1211. doi: 10.1056/NEJM197605272942204. [DOI] [PubMed] [Google Scholar]
  21. Valle M. J., Jordan G. W., Haahr S., Merigan T. C. Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons. J Immunol. 1975 Jul;115(1):230–233. [PubMed] [Google Scholar]
  22. Wheelock E. F., Toy S. T. Participation of lymphocytes in viral infections. Adv Immunol. 1973;16:123–184. doi: 10.1016/s0065-2776(08)60297-7. [DOI] [PubMed] [Google Scholar]
  23. Wilson A. B., Planterose D. N., Nagington J., Park J. R., Barry R. D., Coombs R. R. Influenza A antigens on human lymphocytes in vitro and probably in vivo. Nature. 1976 Feb 19;259(5544):582–584. doi: 10.1038/259582a0. [DOI] [PubMed] [Google Scholar]
  24. Yefenof E., Klein G., Jondal M., Oldstone M. B. Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines. Int J Cancer. 1976 Jun 15;17(6):693–700. doi: 10.1002/ijc.2910170602. [DOI] [PubMed] [Google Scholar]
  25. Zisman B., Denman A. M. Inactivation of myxoviruses by lymphoid cells. J Gen Virol. 1973 Aug;20(2):211–223. doi: 10.1099/0022-1317-20-2-211. [DOI] [PubMed] [Google Scholar]

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