Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1975 Mar;28(3):581–588.

Surface receptors on neutrophils and monocytes from immunodeficient and normal horses.

K L Banks, T C McGuire
PMCID: PMC1445792  PMID: 1126740

Abstract

Surface receptors on peripheral blood neutrophils and monocytes from normal and immunodeficient horses have been studied. Sheep erythrocytes (SRBC) coated with IgG, IgM, and complement but not IgG(T), readily bound to normal equine monocytes and neutrophils. More than 4000 molecules of IgG were required to sensitize each SRBC for adherence to monocytes, and more than 12,000 molecules were required for adherence to neutrophils. Young horses with a severe combined immunodeficiency had an almost total absence of lymphocytes, but normal numbers of monocytes and neutrophils. The number of receptors for immunoglobulin, complement, and phytolectin on monocytes and neutrophils from immunodeficient animals were similar to those on the cells of normal horses. Although the precursor cells of lymphocytes of horses with combined immunodeficiency appear to be defective, no defect in the other cellular products of the bone marrow were apparent.

Full text

PDF
587

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abramson N., Schur P. H. The IgG subclasses of red cell antibodies and relationship to monocyte binding. Blood. 1972 Oct;40(4):500–508. [PubMed] [Google Scholar]
  2. Berken A., Benacerraf B. Properties of antibodies cytophilic for macrophages. J Exp Med. 1966 Jan 1;123(1):119–144. doi: 10.1084/jem.123.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
  4. Clark R. A., Root R. K., Kimball H. R., Kirkpatrick C. H. Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections. Ann Intern Med. 1973 Apr;78(4):515–519. doi: 10.7326/0003-4819-78-4-515. [DOI] [PubMed] [Google Scholar]
  5. Douglas S. D., Goldberg L. S. Monocyte receptors for immunoglobulin and complement in immunologic deficiency diseases. Vox Sang. 1972;23(3):214–217. doi: 10.1111/j.1423-0410.1972.tb04007.x. [DOI] [PubMed] [Google Scholar]
  6. Duquesnoy R. J., Kalpaktsoglou P. K., Good R. A. Immunological studies of the Snell-Bagg pituitary dwarf mouse. Proc Soc Exp Biol Med. 1970 Jan;133(1):201–206. doi: 10.3181/00379727-133-34440. [DOI] [PubMed] [Google Scholar]
  7. Gatti R. A., Good R. A. Macrophage function in severe combined immunodeficiency disease. J Pediatr. 1972 Feb;80(2):285–289. doi: 10.1016/s0022-3476(72)80593-6. [DOI] [PubMed] [Google Scholar]
  8. Gatti R. A., Meuwissen H. J., Allen H. D., Hong R., Good R. A. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet. 1968 Dec 28;2(7583):1366–1369. doi: 10.1016/s0140-6736(68)92673-1. [DOI] [PubMed] [Google Scholar]
  9. Henson P. M. The adherence of leucocytes and platelets induced by fixed IgG antibody or complement. Immunology. 1969 Jan;16(1):107–121. [PMC free article] [PubMed] [Google Scholar]
  10. Huber H., Douglas S. D. Receptor sites on human monocytes for complement: binding of red cells sensitized by cold autoantibodies. Br J Haematol. 1970 Jul;19(1):19–26. doi: 10.1111/j.1365-2141.1970.tb01597.x. [DOI] [PubMed] [Google Scholar]
  11. Huber H., Fudenberg H. H. Receptor sites of human monocytes for IgG. Int Arch Allergy Appl Immunol. 1968;34(1):18–31. doi: 10.1159/000230091. [DOI] [PubMed] [Google Scholar]
  12. Inchley C., Grey H. M., Uhr J. W. The cytophilic activity of human immunoglobulins. J Immunol. 1970 Aug;105(2):362–369. [PubMed] [Google Scholar]
  13. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  14. Lay W. H., Nussenzweig V. Ca++-dependent binding of antigen-19 S antibody complexes to macrophages. J Immunol. 1969 May;102(5):1172–1178. [PubMed] [Google Scholar]
  15. Lay W. H., Nussenzweig V. Receptors for complement of leukocytes. J Exp Med. 1968 Nov 1;128(5):991–1009. doi: 10.1084/jem.128.5.991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Louie J. S., Goldberg L. S. Lymphocyte-monocyte defect associated with anergy and recurrent infections. Clin Exp Immunol. 1972 Jul;11(3):469–474. [PMC free article] [PubMed] [Google Scholar]
  17. Mantovani B., Rabinovitch M., Nussenzweig V. Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J Exp Med. 1972 Apr 1;135(4):780–792. doi: 10.1084/jem.135.4.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. McGuire T. C., Crawford T. B. Identification and quantitation of equine serum and secretory immunoglobulin A. Infect Immun. 1972 Oct;6(4):610–615. doi: 10.1128/iai.6.4.610-615.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McGuire T. C., Poppie M. J., Banks K. L. Combined (B- and T-lymphocyte) immunodeficiency: a fatal genetic disease in Arabian foals. J Am Vet Med Assoc. 1974 Jan 1;164(1):70–76. [PubMed] [Google Scholar]
  20. McGuire T. C., Poppie M. J. Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder. Infect Immun. 1973 Aug;8(2):272–277. doi: 10.1128/iai.8.2.272-277.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Nowell P. C., Wilson D. B. Lymphocytes and hemic stem cells. Am J Pathol. 1971 Dec;65(3):641–651. [PMC free article] [PubMed] [Google Scholar]
  22. PORTER R. R. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J. 1959 Sep;73:119–126. doi: 10.1042/bj0730119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Pantelouris E. M. Absence of thymus in a mouse mutant. Nature. 1968 Jan 27;217(5126):370–371. doi: 10.1038/217370a0. [DOI] [PubMed] [Google Scholar]
  24. Rabellino E., Colon S., Grey H. M., Unanue E. R. Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med. 1971 Jan 1;133(1):156–167. doi: 10.1084/jem.133.1.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Snyderman R., Altman L. C., Frankel A., Blaese R. M. Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. Ann Intern Med. 1973 Apr;78(4):509–513. doi: 10.7326/0003-4819-78-4-509. [DOI] [PubMed] [Google Scholar]
  26. Steerman R. L., Snyderman R., Leikin S. L., Colten H. R. Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. Clin Exp Immunol. 1971 Dec;9(6):939–946. [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES