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. 1975 Jul;29(1):103–113.

Cells involved in the immune response. XXVIII. the cellular composition of the lymphoid organs in the normal outbred rabbit.

M Richter, C De La Noue, H Hamdy
PMCID: PMC1445875  PMID: 1140823

Abstract

Horse anti-rabbit spleen cell antiserum was obtained by the intravenous immunization of horses with rabbit spleen cells. The antisera obtained were analysed for their lymphocytotoxic activity with respect to the lymphoid cells of the different lymphoid organs prior to and following absorption with the different lymphoid cells. The results have been integrated with those obtained in previous investigations and an all-embracing concept of the interrelationship of the lymphoid cells in the different lymphoid organs in the rabbit has emerged. The distinction between the heretofore considered central lymphoid organs (bone marrow and thymus) and peripheral lymphoid organs (spleen, lymph node and appendix) has been blurred by the finding that, at least in the rabbit, appendix cells possess specific antigen markers and participate in cell-mediated immune reactions in vitro and the observation that the spleen also has a central lymphoid function in the generation of cells in vivo capable of carrying out a cell-mediated immune reaction in vitro. It is concluded that the distinction of central and peripheral lymphoid function may be an artificial one in that it may reflect a function of the particular organ in only one of the many different types of immune reactions and that it should not influence the investigator in the elucidation of the cellular mechanisms participating in the mediation of the different immune responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARNASON B. G., JANKOVIC B. D., WAKSMAN B. H., WENNERSTEN C. Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte. J Exp Med. 1962 Aug 1;116:177–186. doi: 10.1084/jem.116.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abdou N. I., Richter M. Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells. J Exp Med. 1969 Apr 1;129(4):757–774. doi: 10.1084/jem.129.4.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ablin R. J., Morris A. J. Thymus-specific antigens on human thymocytes and on thymic-derived lymphocytes. Transplantation. 1973 Apr;15(4):415–417. doi: 10.1097/00007890-197304000-00014. [DOI] [PubMed] [Google Scholar]
  4. Behelak Y., Shibata H., Richter M. Cells involved in cell-mediated and transplantation immunity in the rabbit. V. The loss of effector cells following extirpation of the spleen or the appendix, sacculus rotundus, and Peyer's patches. Cell Immunol. 1973 Apr;7(1):108–117. doi: 10.1016/0008-8749(73)90186-x. [DOI] [PubMed] [Google Scholar]
  5. Claman H. N., Chaperon E. A. Immunologic complementation between thymus and marrow cells--a model for the two-cell theory of immunocompetence. Transplant Rev. 1969;1:92–113. doi: 10.1111/j.1600-065x.1969.tb00137.x. [DOI] [PubMed] [Google Scholar]
  6. Colas de la Noue H., Richter M. Cells involved in the immune response. XXVI. The demonstration of bone marrow-specific antigens in the rabbit. Immunology. 1974 Sep;27(3):413–420. [PMC free article] [PubMed] [Google Scholar]
  7. Cooper M. D., Perey D. Y., Gabrielsen A. E., Sutherland D. E., McKneally M. F., Good R. A. Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues. Int Arch Allergy Appl Immunol. 1968;33(1):65–88. doi: 10.1159/000229975. [DOI] [PubMed] [Google Scholar]
  8. Cooper M. D., Raymond D. A., Peterson R. D., South M. A., Good R. A. The functions of the thymus system and the bursa system in the chicken. J Exp Med. 1966 Jan 1;123(1):75–102. doi: 10.1084/jem.123.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DRAPER L. R., SUSSDORF D. H. The primary hemolysin response in rabbits following shielding from x rays of x irradiation of the spleen, appendix, liver or hind legs. J Infect Dis. 1956 Sep-Oct;99(2):129–142. doi: 10.1093/infdis/99.2.129. [DOI] [PubMed] [Google Scholar]
  10. Daguillard F., Richter M. Cells involved in the immune response. XII. The differing responses of normal rabbit lymphoid cells to phytohemagglutinin, goat anti-rabbit immunoglobulin antiserum and allogeneic and xenogeneic lymphocytes. J Exp Med. 1969 Nov 1;130(5):1187–1208. doi: 10.1084/jem.130.5.1187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Davies A. J. The thymus and the cellular basis of immunity. Transplant Rev. 1969;1:43–91. doi: 10.1111/j.1600-065x.1969.tb00136.x. [DOI] [PubMed] [Google Scholar]
  12. Fulginiti V. A., Hathaway W. E., Pearlman D. S., Blackburn W. R., Reiquam C. W., Githens J. H., Claman H. N., Kempe C. H. Dissociation of delayed-hypersensitivy and antibody-synthesising capacities in man. Report of two sibships with thymic dysplasia, lymphoid tissue depletion, and normal immunoglobulins. Lancet. 1966 Jul 2;2(7453):5–8. doi: 10.1016/s0140-6736(66)91742-9. [DOI] [PubMed] [Google Scholar]
  13. Gatti R. A., Good R. A. The immunological deficiency diseases. Med Clin North Am. 1970 Mar;54(2):281–307. [PubMed] [Google Scholar]
  14. Gatti R. A., Stutman O., Good R. A. The lymphoid system. Annu Rev Physiol. 1970;32:529–546. doi: 10.1146/annurev.ph.32.030170.002525. [DOI] [PubMed] [Google Scholar]
  15. Komuro K., Boyse E. A. Induction of T lymphocytes from precursor cells in vitro by a product of the thymus. J Exp Med. 1973 Aug 1;138(2):479–482. doi: 10.1084/jem.138.2.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McKneally M. F., Sutherland D. E., Good R. A. The central lymphoid tissues of rabbits. II. Functional and morphologic studies in adult animals. Surgery. 1971 Mar;69(3):345–353. [PubMed] [Google Scholar]
  17. Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
  18. Miller J. F., Osoba D. Current concepts of the immunological function of the thymus. Physiol Rev. 1967 Jul;47(3):437–520. doi: 10.1152/physrev.1967.47.3.437. [DOI] [PubMed] [Google Scholar]
  19. Motta R. Utilisation du test "d'inhibition de cytotoxicité" pour le dosage de l'antigène de greffe "in vitro" chez la souris. Rev Fr Etud Clin Biol. 1968 Aug-Sep;13(7):713–720. [PubMed] [Google Scholar]
  20. Ozer H., Waksman B. H. Appendix and gamma-M antibody formation. IV. Synergism of appendix and bone marrow cells in early antibody response to sheep erythrocytes. J Immunol. 1970 Sep;105(3):791–792. [PubMed] [Google Scholar]
  21. Perey D. Y., Frommel D., Hong R., Good R. A. The mammalian homologue of the avian bursa of Fabricius. II. Extirpation, lethal x-irradiation, and reconstitution in rabbits. Effects on humoral immune responses, immunoglobulins, and lymphoid tissues. Lab Invest. 1970 Mar;22(3):212–227. [PubMed] [Google Scholar]
  22. Playfair J. H. Cell cooperation in the immune response. Clin Exp Immunol. 1971 Jun;8(6):839–856. [PMC free article] [PubMed] [Google Scholar]
  23. Raff M. C., Nase S., Mitchison N. A. Mouse specific bone marrow-derived lymphocyte antigen as a marker for thymus-independent lymphocytes. Nature. 1971 Mar 5;230(5288):50–51. doi: 10.1038/230050a0. [DOI] [PubMed] [Google Scholar]
  24. Raff M. C. Surface antigenic markers for distinguishing T and B lymphocytes in mice. Transplant Rev. 1971;6:52–80. doi: 10.1111/j.1600-065x.1971.tb00459.x. [DOI] [PubMed] [Google Scholar]
  25. Richter M., Algom D. The heterogeneity of lymphocytes. A consideration of future developments and their impact on clinical medicine. Med Clin North Am. 1972 Mar;56(2):305–317. doi: 10.1016/s0025-7125(16)32398-7. [DOI] [PubMed] [Google Scholar]
  26. Schlesinger M., Yron I. Antigenic changes in lymph-node cells after administration of antiserum to thymus cells. Science. 1969 Jun 20;164(3886):1412–1413. doi: 10.1126/science.164.3886.1412. [DOI] [PubMed] [Google Scholar]
  27. Singhal S. K., Richter M. Cells involved in the immune response. IV. The response of normal and immune rabbit bone marrow and lymphoid tissue lymphocytes to antigens in vitro. J Exp Med. 1968 Nov 1;128(5):1099–1128. doi: 10.1084/jem.128.5.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Taylor R. B. Cellular cooperation in the antibody response of mice to two serum albumins: specific function of thymus cells. Transplant Rev. 1969;1:114–149. doi: 10.1111/j.1600-065x.1969.tb00138.x. [DOI] [PubMed] [Google Scholar]
  29. WAKSMAN B. H., ARNASON B. G., JANKOVIC B. D. Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organs of thymectomized rats. J Exp Med. 1962 Aug 1;116:187–206. doi: 10.1084/jem.116.2.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Waksman B. H., Ozer H., Blythman H. E. Appendix and M-antibody formation. VI. The functional anatomy of the rabbit appendix. Lab Invest. 1973 May;28(5):614–626. [PubMed] [Google Scholar]
  31. Williams R. M., Chanana A. D., Cronkite E. P., Waksman B. H. Antigenic markers on cells leaving calf thymus by way of the efferent lymph and venous blood. J Immunol. 1971 May;106(5):1143–1146. [PubMed] [Google Scholar]
  32. Zatz M. M., Lance E. M. The distribution of chromium 51-labelled lymphoid cells in the mouse. A survey of anatomical compartments. Cell Immunol. 1970 May;1(1):3–17. doi: 10.1016/0008-8749(70)90057-2. [DOI] [PubMed] [Google Scholar]
  33. el-Arini M. O., Osoba D. Differentiation of thymus-derived cells from precursors in mouse bone marrow. J Exp Med. 1973 Mar 1;137(3):821–837. doi: 10.1084/jem.137.3.821. [DOI] [PMC free article] [PubMed] [Google Scholar]

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