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. 2006 Apr;26(8):2936–2946. doi: 10.1128/MCB.26.8.2936-2946.2006

FIG. 2.

FIG. 2.

Spatial memory formation in the Morris water maze task is impaired in tTA/IκBα-AA double transgenic mice. (A) Every group improved with training; however, significant, longer escape times are observed in tTA/IκBα-AA double transgenic mice in the absence of DOX compared to untreated single transgenic controls (*, P < 0.05). The number of subjects used is indicated in parentheses. DOX treatment of single or double transgenics did not significantly affect learning abilities. (B) Significantly reduced percent time in target quadrant after 5 days' rest in tTA/IκBα-AA double transgenic mice in the absence of DOX relative to untreated single transgenic controls (*, P < 0.002). P values for comparisons for all groups are the following: IκBα-AA versus IκBα-AA+DOX, P < 0.036; IκBα-AA versus tTA/IκBα-AA+DOX, P < 0.066; IκBα-AA+DOX versus tTA/IκBα-AA+DOX, P < 0.87; tTA/IκBα-AA versus IκBα-AA+DOX, P < 0.3; tTA/IκBα-AA versus tTA/IκBα-AA+DOX, P < 0.22; tTA/IκBα-AA versus IκBα-AA, P < 0.002. These values reveal that DOX treatment has by itself a significant influence on memory formation. Data are means ± standard errors of the means.