Skip to main content
. 2006 Apr;26(8):2936–2946. doi: 10.1128/MCB.26.8.2936-2946.2006

FIG. 6.

FIG. 6.

Inhibition of NF-κB interferes with PKA-dependent CREB phosphorylation. (A) Immunocytochemistry of CREB-phosphorylation on hippocampal slice cultures from tTA/IκBα-AA double transgenic mice or IκBα-AA single transgenic littermate controls, untreated or treated with forskolin for 30 min. CA1, hippocampal region CA1; CA3, hippocampal region CA3. (B) Quantification of the total number of pCREB-positive nuclei in the hippocampal fields observed in panel A (n = 3 mice/genotype). The average values of forskolin-induced CREB phosphorylation are significantly higher in IκBα-AA single transgenic slices relative to tTA/IκBα-AA double trangenics (**, P < 0.01), whereas no significant differences could be observed between forskolin-treated tTA/IκBα-AA double transgenic slices and untreated single (IκBα-AA) or double (tTA/IκBα-AA) transgenics.