TABLE 3.
Clinical observations of MOG peptide-induced EAEa
Group | Incidence of EAE | Avg score | No. of deaths |
---|---|---|---|
Wild type | 26/32 | 1.95 ± 0.2 | 10/32 |
TRIM−/− | 25/33 | 1.75 ± 0.2 | 8/33 |
Disease severity was scored according to a scale from 0 to 5: 0, no signs; 0.5, partial tail weakness; 1, limp tail or slight slowing of righting from supine position; 2, paresis of hind limb or marked slowing of righting; 2.5, dragging of hind limb(s) without complete paralysis; 3, complete paralysis of hind limb; 4, severe forelimb paralysis; 5, moribund or dead. In respect of the animal protection laws, mice were killed when they reached a score of 3 and received this last score until the end of the experiment.