TABLE 1.
Weights of organs, sperm parameters, and serum testosterone levels in Tslc1−/− and Tslc1+/+ mice
| Parameter | Value for Tslc1−/− mice | No. of mice analyzed | Value for Tslc1+/+ mice | No. of mice analyzed | P valueb |
|---|---|---|---|---|---|
| Total body wt (g) (25 wks) | 38.7 ± 2.8 | 4 | 37.8 ± 1.6 | 4 | NS |
| Wet wt of organs (mg)a | |||||
| Brain | 425 ± 10 | 3 | 442 ± 7.9 | 4 | NS |
| Eye | 25.5 ± 0.4 | 5 | 24.4 ± 2.1 | 3 | NS |
| Thymus | 38.7 ± 0.9 | 3 | 42.4 ± 2.2 | 3 | NS |
| Lung | 174 ± 28 | 3 | 181 ± 7.2 | 4 | NS |
| Heart | 222 ± 23 | 5 | 189 ± 19 | 4 | NS |
| Spleen | 85.5 ± 19 | 5 | 94 ± 5.0 | 4 | NS |
| Kidney | 318 ± 22 | 5 | 309 ± 22 | 4 | NS |
| Liver | 1,900 ± 80 | 5 | 1,770 ± 260 | 4 | NS |
| Stomach | 420 ± 54 | 4 | 405 ± 54 | 3 | NS |
| Intestinum tenue, pancreas, and mesenterium | 2,310 ± 130 | 5 | 2,470 ± 280 | 4 | NS |
| Intestinum crassum | 584 ± 78 | 3 | 651 ± 47 | 3 | NS |
| Seminal vesicle | 163 ± 14 | 4 | 153 ± 4.2 | 4 | NS |
| Bladder and prostate | 133 ± 18 | 4 | 143 ± 10 | 4 | NS |
| Epididymis and vas deferens | 59.4 ± 9.5 | 5 | 85.1 ± 13 | 4 | NS |
| Testis | 94.7 ± 3.0 | 5 | 134 ± 8.7 | 4 | 0.003 |
| Sperm parameters (11 wks) | |||||
| Total no. of cells (106) | 7.3 ± 1.0 | 3 | 20 ± 2.4 | 3 | 0.008 |
| No. of normal sperm (103) | 1.2 ± 0.8 | 3 | 15,000 ± 2,200 | 3 | 0.002 |
| Motile sperm/normal sperm (%) | 1.1 ± 0.4 | 3 | 83.3 ± 3.3 | 3 | <0.0001 |
| Serum testosterone level (ng/ml) | |||||
| 16 wks | 4.5 ± 4.0 | 3 | 2.5 ± 2.0 | 3 | NS |
| 25 wks | 1.7 ± 0.5 | 4 | 3.2 ± 3.0 | 4 | NS |
a
Brains and lungs were from 16-week-old mice. Other organs were from 25-week-old mice. For each animal, the wet weights of paired organs were averaged, and this single value was used to calculate the means±SE.
b
NS, not significant.