TABLE 4.

Comparison of the transcriptomes of L. lactis MGbcaP and L. lactis MG1363

Transcriptional unita	Expression ratiob	Significance (P value)	Descriptionc	Regulon
dppA, P, B, C, D, F	4.5	10−8	Dipeptide transport system	CodY
ybbE	3.0	10−13	Hypothetical protein, downstream of bcaP
llmg_0328	2.4	10−6	Hypothetical protein
comX	2.2	10−9	Putative regulator
gltA, citB, icD	2.1	10−13	Krebs TCA cycle enzymes	CodY
leuC, A	2.0	10−9	Leucine biosynthesis	CodY
hisC, Z, G, D, B, ymdC, hisH, A, F, I, K	1.9	10−10	Histidine biosynthesis	CodY
metC-cysK	1.9	10−8	Methionine/cysteine synthesis	CmbR
rmaG	1.9	10−4	Transcriptional regulator
llmg_1066	1.8	10−6	Putative membrane protein
llmg_0472/0473	1.7	10−5	Hypothetical proteins
ilvD, B, N, C, A, aldB	1.6	10−7	BCAA biosynthesis	CodY
fabI	1.6	10−5	Enoyl-ACP reductase
purC, H	1.6	10−7	Purine synthesis	CmbR
cysD	1.6	10−11	O-Acetylserine sulfhydrylase	CmbR
ydbE	1.6	10−4	Hypothetical protein
glgD	1.6	10−6	Glucose-1-phosphate adenylyltransferase	CmbR?
yrbB	1.5	10−10	Hypothetical protein
yriD	1.5	10−6	Hypothetical protein	CmbR
cysM	1.5	10−7	Cysteine synthase	CmbR
cpo	0.7	10−6	Hydrolase or acyltransferase
yrcA	0.7	10−7	Phospho-beta-glucosidase
yjaE	0.7	10−4	Hypothetical protein
ynjC	0.7	10−4	Hypothetical protein
argF	0.7	10−6	Ornithine carbamoyltransferase
yedF	0.6	10−7	PTS II ABC component
trpB	0.6	10−6	Tryptophan synthase beta chain
butB	0.6	10−6	Dehydrogenase
ptcA	0.6	10−5	Cellobiose-PTS component
panE	0.6	10−9	Ketopantoate reductase
fruA	0.6	10−5	Fructose-PTS component
pgmB	0.5	10−9	Beta-phosphoglucomutase
busAB	0.5	10−8	Betaine ABC transporter
cstA	0.5	10−4	Carbon starvation protein
bglS, ybhD	0.5	10−6	Beta-glucosidase A, hypothetical protein
yecA	0.5	10−5	Transcriptional regulator
chiA, yucG	0.4	10−5	Chitinase, chitin-binding protein
rcfB, yxbD	0.4	10−4	Transcriptional regulator, transporter
argH	0.4	10−7	Argininosuccinate lyase
yjjA	0.3	10−14	Hypothetical protein

^aThe gene (in an operon) that shows the highest ratio of expression is underlined.

^bRatio of expression in L. lactis MGbcaP over that in L. lactis MG1363.

^c(Putative) gene function. TCA, tricarboxylic acid; ACP, acyl carrier protein; PTS, phosphotransferase system.