Table 4.

Pharmacokinetic parameters of cassette vs. individual dosing following oral gavage in mice at a 5 mg/kg close of sEH inhibitors

	AUDA		ADU
	Individual	Cassette	Individual	Cassette
γz(h-1)a	0.17 ± 0.05	0.15 ± 0.05	0.13 ± 0.05	0.08 ± 0.005†
Tmax (h)b	0.7 ± 0.2	0.7 ± 0.3	1.0 ± 0.0	1.3 ± 0.6
Cmax (ng/mL)c	26 ± 12	29 ± 11	21 ± 19	17 ± 7
T ½ (h)d	4.4 ± 1.3	48 ± 1.3	6.2 ± 3.3	8.7 ± 0.6
AUC9 (ng/mL h)e	75 ± 7	53 ± 8	38 ± 2	32 ± 9
AUCt (ng/mL h)f	115 ± 14	66 ± 12*	43 ±23	37 ± 5
AUC8 (ng/mL h)g	133 ± 18	69 ± 12*	44 ± 22	40 ± 4
MRT (h)h	7.9 ± 2.6	4.9 ± 0.4	3.9 ± 0.9	4.2 ± 2.1

Results are means S.D. from four animals.

^aElimination rate constant.

^bTime of maximum concentration.

^cMaximum concentration.

^dElimination half-life.

^eArea under the concentration (0-9).

^fArea under the concentration (0-t).

^gArea under the concentration (0-m).

^hMean residence time.

^†Significantly different from individual using F-test (p < 0.05).

^*Significantly different from individual by T-test (p < 0.05).