Table 6.
Results of 5 × 2 Cross-validation on Data Set for Each Drug Review
| Drug Review | WSS@95% | w | FNLR | P | R | F | WSS |
|---|---|---|---|---|---|---|---|
| ACEInhibitors | 56.61% | 0.25 | 15.2620 | 0.1211 | 0.6293 | 0.2031 | 54.55% |
| 0.5 | 30.5240 | 0.0949 | 0.8098 | 0.1699 | 67.23% | ||
| 0.75 | 45.7870 | 0.0761 | 0.8732 | 0.1400 | 68.82% | ||
| 1 | 61.0490 | 0.0642 | 0.8780 | 0.1197 | 65.77% | ||
| *2 | 122.0980 | 0.0387 | 0.9561 | 0.0745 | 55.84% | ||
| 4 | 244.1950 | 0.0238 | 0.9854 | 0.0465 | 31.81% | ||
| 8 | 488.3900 | 0.0183 | 1.0000 | 0.0359 | 11.75% | ||
| ADHD | 67.95% | 0.25 | 10.3870 | 0.1379 | 0.6300 | 0.2262 | 52.26% |
| 0.5 | 20.7750 | 0.0998 | 0.8500 | 0.1786 | 64.98% | ||
| *0.75 | 31.1630 | 0.0945 | 0.9200 | 0.1713 | 69.11% | ||
| 1 | 41.5500 | 0.0738 | 0.9800 | 0.1373 | 66.79% | ||
| 2 | 83.1000 | 0.0436 | 1.0000 | 0.0835 | 46.09% | ||
| 4 | 166.2000 | 0.0292 | 1.0000 | 0.0568 | 19.53% | ||
| 8 | 332.4000 | 0.0249 | 1.0000 | 0.0486 | 5.57% | ||
| Antihistamines | 0.00% | 0.25 | 4.5940 | 0.0894 | 0.1375 | 0.1084 | 5.81% |
| 0.5 | 9.1880 | 0.0798 | 0.2125 | 0.1160 | 7.51% | ||
| 0.75 | 13.7810 | 0.0737 | 0.3125 | 0.1193 | 9.38% | ||
| 1 | 18.3750 | 0.0714 | 0.3625 | 0.1193 | 10.06% | ||
| 2 | 36.7500 | 0.0600 | 0.5125 | 0.1075 | 7.19% | ||
| 4 | 73.5000 | 0.0502 | 0.8500 | 0.0948 | −2.35% | ||
| 8 | 147.0000 | 0.0488 | 0.8500 | 0.0923 | −4.87% | ||
| AtypicalAntipsychotics | 14.11% | 0.25 | 1.6680 | 0.3890 | 0.2712 | 0.3196 | 18.03% |
| 0.5 | 3.3360 | 0.3239 | 0.5014 | 0.3935 | 29.96% | ||
| 0.75 | 5.0030 | 0.2701 | 0.6027 | 0.3730 | 31.18% | ||
| 1 | 6.6710 | 0.2527 | 0.7014 | 0.3716 | 33.96% | ||
| 2 | 13.3420 | 0.1968 | 0.8479 | 0.3194 | 28.62% | ||
| *4 | 26.6850 | 0.1534 | 0.9493 | 0.2642 | 14.27% | ||
| 8 | 53.3700 | 0.1362 | 0.9932 | 0.2396 | 4.28% | ||
| BetaBlockers | 28.44% | 0.25 | 12.0830 | 0.1253 | 0.4905 | 0.1996 | 41.11% |
| 0.5 | 24.1670 | 0.0799 | 0.6429 | 0.1422 | 47.98% | ||
| 0.75 | 36.2500 | 0.0621 | 0.7381 | 0.1146 | 49.72% | ||
| 1 | 48.3330 | 0.0503 | 0.8190 | 0.0948 | 48.91% | ||
| *2 | 96.6670 | 0.0334 | 0.9286 | 0.0644 | 36.47% | ||
| 4 | 193.3330 | 0.0257 | 0.9714 | 0.0500 | 20.42% | ||
| 8 | 386.6670 | 0.0226 | 0.9952 | 0.0443 | 10.39% | ||
| CalciumChannelBlockers | 12.21% | 0.25 | 2.7950 | 0.2756 | 0.3440 | 0.3060 | 24.15% |
| 0.5 | 5.5900 | 0.2259 | 0.5620 | 0.3222 | 35.77% | ||
| 0.75 | 8.3850 | 0.1968 | 0.6460 | 0.3017 | 37.65% | ||
| 1 | 11.1800 | 0.1694 | 0.6760 | 0.2709 | 34.84% | ||
| 2 | 22.3600 | 0.1248 | 0.8840 | 0.2188 | 30.26% | ||
| *4 | 44.7200 | 0.0952 | 0.9460 | 0.1730 | 13.02% | ||
| 8 | 89.4400 | 0.0845 | 0.9960 | 0.1558 | 2.83% | ||
| Estrogens | 18.34% | 0.25 | 0.9000 | 0.4953 | 0.2625 | 0.3431 | 14.73% |
| 0.5 | 1.8000 | 0.4648 | 0.5275 | 0.4941 | 28.08% | ||
| 0.75 | 2.7000 | 0.4288 | 0.6775 | 0.5252 | 33.40% | ||
| 1 | 3.6000 | 0.3968 | 0.7500 | 0.5190 | 33.91% | ||
| 2 | 7.2000 | 0.3213 | 0.8900 | 0.4721 | 28.78% | ||
| *4 | 14.4000 | 0.2552 | 0.9725 | 0.4044 | 14.42% | ||
| 8 | 28.8000 | 0.2263 | 0.9975 | 0.3689 | 3.93% | ||
| NSAIDs | 49.67% | 0.25 | 2.1460 | 0.3720 | 0.3756 | 0.3738 | 27.03% |
| 0.5 | 4.2930 | 0.3453 | 0.7024 | 0.4630 | 49.02% | ||
| 0.75 | 6.4390 | 0.2831 | 0.8146 | 0.4201 | 51.44% | ||
| *1 | 8.5850 | 0.2631 | 0.9317 | 0.4103 | 56.22% | ||
| 2 | 17.1710 | 0.1620 | 0.9902 | 0.2785 | 35.26% | ||
| 4 | 34.3410 | 0.1161 | 1.0000 | 0.2081 | 10.18% | ||
| 8 | 68.6830 | 0.1080 | 1.0000 | 0.1950 | 3.41% | ||
| Opioids | 13.32% | 0.25 | 31.6670 | 0.0347 | 0.2533 | 0.0610 | 19.61% |
| 0.5 | 63.3330 | 0.0187 | 0.4667 | 0.0359 | 27.09% | ||
| 0.75 | 95.0000 | 0.0128 | 0.4533 | 0.0249 | 17.57% | ||
| 1 | 126.6670 | 0.0109 | 0.6933 | 0.0214 | 19.44% | ||
| *2 | 253.3330 | 0.0092 | 0.9467 | 0.0182 | 14.19% | ||
| 4 | 506.6670 | 0.0082 | 0.9867 | 0.0162 | 3.85% | ||
| 8 | 1013.3338 | 0.0078 | 1.0000 | 0.0156 | 0.05% | ||
| OralHypoglycemics | 8.96% | 0.25 | 0.6750 | 0.5437 | 0.2471 | 0.3397 | 12.42% |
| 0.5 | 1.3490 | 0.4840 | 0.4882 | 0.4861 | 21.55% | ||
| 0.75 | 2.0240 | 0.4284 | 0.5941 | 0.4978 | 21.92% | ||
| 1 | 2.6990 | 0.3962 | 0.6735 | 0.4989 | 21.39% | ||
| 2 | 5.3970 | 0.3375 | 0.8382 | 0.4812 | 16.67% | ||
| *4 | 10.7940 | 0.3004 | 0.9471 | 0.4561 | 9.46% | ||
| 8 | 21.5880 | 0.2797 | 0.9838 | 0.4355 | 3.27% | ||
| ProtonPumpInhibitors | 27.68% | 0.25 | 6.2840 | 0.2335 | 0.4706 | 0.3121 | 39.35% |
| 0.5 | 12.5690 | 0.1522 | 0.6588 | 0.2472 | 49.32% | ||
| 0.75 | 18.8530 | 0.1162 | 0.7059 | 0.1996 | 47.35% | ||
| 1 | 25.1370 | 0.0879 | 0.7882 | 0.1582 | 44.52% | ||
| *2 | 50.2750 | 0.0602 | 0.9373 | 0.1132 | 34.18% | ||
| 4 | 100.5490 | 0.0471 | 0.9686 | 0.0898 | 18.18% | ||
| 8 | 201.0980 | 0.0412 | 0.9961 | 0.0792 | 7.17% | ||
| SkeletalMuscleRelaxants | 0.00% | 0.25 | 45.3890 | 0.0042 | 0.0222 | 0.0070 | −0.70% |
| 0.5 | 90.7780 | 0.0038 | 0.0222 | 0.0064 | −1.02% | ||
| 0.75 | 136.1670 | 0.0044 | 0.3556 | 0.0088 | −8.34% | ||
| 1 | 181.5560 | 0.0050 | 0.4000 | 0.0099 | −3.90% | ||
| 2 | 363.1110 | 0.0051 | 0.8444 | 0.0102 | −5.56% | ||
| 4 | 726.2220 | 0.0055 | 1.0000 | 0.0109 | 0.00% | ||
| 8 | 1452.4440 | 0.0055 | 1.0000 | 0.0109 | 0.00% | ||
| Statins | 24.71% | 0.25 | 9.9410 | 0.1707 | 0.5106 | 0.2559 | 43.72% |
| 0.5 | 19.8820 | 0.1154 | 0.6612 | 0.1965 | 52.06% | ||
| 0.75 | 29.8240 | 0.0883 | 0.7600 | 0.1583 | 54.89% | ||
| 1 | 39.7650 | 0.0702 | 0.8071 | 0.1291 | 52.49% | ||
| 2 | 79.5290 | 0.0469 | 0.8894 | 0.0891 | 42.44% | ||
| *4 | 159.0590 | 0.0311 | 0.9647 | 0.0603 | 20.41% | ||
| 8 | 318.1180 | 0.0263 | 0.9906 | 0.0512 | 6.55% | ||
| Triptans | 3.37% | 0.25 | 6.7400 | 0.1389 | 0.2500 | 0.1786 | 18.56% |
| 0.5 | 13.4790 | 0.0883 | 0.5583 | 0.1524 | 33.21% | ||
| 0.75 | 20.2190 | 0.0711 | 0.6917 | 0.1290 | 34.38% | ||
| 1 | 29.9580 | 0.0639 | 0.7583 | 0.1178 | 33.36% | ||
| 2 | 53.9170 | 0.0449 | 0.8667 | 0.0854 | 17.64% | ||
| *4 | 107.8330 | 0.0365 | 0.9583 | 0.0703 | 1.94% | ||
| 8 | 215.6670 | 0.0359 | 1.0000 | 0.0693 | 0.39% | ||
| UrinaryIncontinence | 26.14% | 0.25 | 1.7940 | 0.4509 | 0.5050 | 0.4764 | 36.80% |
| 0.5 | 3.5870 | 0.3434 | 0.7400 | 0.4691 | 47.64% | ||
| 0.75 | 5.3810 | 0.2824 | 0.7400 | 0.4088 | 41.95% | ||
| 1 | 7.1750 | 0.2523 | 0.8400 | 0.3880 | 43.27% | ||
| 2 | 14.3500 | 0.1880 | 0.9100 | 0.3116 | 31.80% | ||
| *4 | 28.7000 | 0.1559 | 0.9850 | 0.2691 | 21.19% | ||
| 8 | 57.4000 | 0.1325 | 1.0000 | 0.2341 | 7.71% |
WSS = work saved over sampling; w = normalized FNLR parameter; FNLR = false-negative learning rate; P = precision; R = recall; F = F1-measure; ACE = angiotensin-converting enzyme; ADHD = attention-deficit/hyperactivity disorder; NSAIDs = nonsteroidal anti-inflammatory drugs; * = recall closest to 0.95.